Regulation by Covalent Modification

The preceding chapter showed that the regulation of enzymatic activity can be carried out through a variety of mechanisms. Regulation involving covalent processes is even more diverse. These processes include various co- and post-translational events such as limited proteolysis and various chemical modifications (glycosylation, carboxylation, ADP-ribosylation etc.). They also involve mechanisms of enzyme phosphorylation-dephosphorylation, catalysed by specific enzymes, as a function of the cell’s metabolic needs or in response to signals.

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Features and regulation of non-enzymatic post-translational modifications

Introduction to Sumoylation

Closure – Whither Enzymology

Bibliography

Books

• A lberts B. et al. –1983– Molecular Biology of the Cell, Garland publisher, New York. Google Scholar

General Reviews

• C oux O., T anaka K. & G oldberg A.L. –1996– Structure and function of the 20 s and 26 s proteasome, in Annu. Rev. Biochem.65, 801. ArticlePubMedCASGoogle Scholar
• G rütter M.G. –2000– Caspases: key players in programmed cell death, in Curr. Op. Struct. Biol.10, 649–655. ArticleGoogle Scholar
• H ayes B.K. & H art G. –1994– Novel forms of protein glycosylation, in Curr. Op. Struct. Biol.4, 692–696. ArticleCASGoogle Scholar
• H engartner M.O. –2000– The biochemistry of apoptosis, in Nature407, 770–776. ArticlePubMedCASGoogle Scholar
• L askowski M. JR & K ato I. –1980– Protein inhibitors of proteinases, in Annu. Rev. Biochem.49, 593–626. ArticlePubMedCASGoogle Scholar
• S tadtman E.R. & C hock P.B. –1978– Interconvertible enzyme cascades in metabolic regulation, in Curr. Top. Cell. Regul.13, 53–95. PubMedCASGoogle Scholar

Specialised Articles

• A hn K., E rlander M., L eturcq D., P eterson P.A., F rüh K & Y ang Y. –1996– J. Biol. Chem.271, 18237. ArticlePubMedCASGoogle Scholar
• A lmassy R.J., J anson C.A., H amlin R., X uong N.H. & E isenberg D. –1986– Nature323, 304. ArticlePubMedCASGoogle Scholar
• B arford D., H u S.H. & J ohnson L.N. –1991– J. Mol. Biol.218, 233. ArticlePubMedCASGoogle Scholar
• B ode W. & H uber R. –1992– Eur. J. Biochem.204, 433. ArticlePubMedCASGoogle Scholar
• C arrell R.W., E vans D.L. & S tein P.E. –1991– Nature353, 576. ArticlePubMedCASGoogle Scholar
• C hambon P., W eill J.D., D oly J., S trosser M.T. & M andel P. –1966– Biochem. Biophys. Res. Commun.25, 638. ArticleCASGoogle Scholar
• D avie E.W., F ujikawa K. & K isiel W. –1991– Biochemistry30, 10363. ArticlePubMedCASGoogle Scholar
• F isher E.H. & K rebs E.G. –1955– J. Biol. Chem.216, 121. Google Scholar
• G aal J.C. & P earson C.K. –1986– Trends Biochem. Sci.11, 171. ArticleCASGoogle Scholar
• G aboriaud G., R ossi V., B ally I., A rland G.J. & F ontecilla -C amps J.C. –2000– Embo. J.19, 1755. ArticlePubMedCASGoogle Scholar
• G roll M., D itzel L., S tock D., B ochtler M., B artunik H. & H iber R. –1997– Nature386, 463. ArticlePubMedCASGoogle Scholar
• H anks S.K. & Q uinn A.M. –1991– Methods Enzymol.200, 38. ArticlePubMedCASGoogle Scholar
• H ervé M. & G hélis C. –1991– Arch. Biochem. Biophys.285, 142. ArticlePubMedGoogle Scholar
• H unter T. –1991– Methods Enzymol.200, 3. ArticlePubMedCASGoogle Scholar
• K nighton D.R., Z heng J., T en E yck L.F., A shford V.A., X uong N.H., T aylor S.S. & S owadski J.M. –1991– Science253, 407 and 414. ArticlePubMedCASGoogle Scholar
• K obata A. –1995– Glycobiology, in Molecular Biology and Biotechnology, R.A. Meyers ed., New York, 382–385. Google Scholar
• L öwe J., S tock D., J ap B., A wicker P., B aumeister W. & Huber R. –1995– Science 268, 533. ArticlePubMedGoogle Scholar
• M archase R.B., B ounelis P., B rumley L.M., D ey N., B rowne B., A uger D., F ritz T.A., K ulesza P. & B edwell D.M. –1993– J. Biol. Chem.268, 8341. PubMedCASGoogle Scholar
• N icholson D.W. & T hornberry N.A. –1997– TIBS22, 299. PubMedCASGoogle Scholar
• R ay A.K., D atta B., C hakraborty A., C hattopadhyay A., M eza -K euther S. & G upta N.K. –1992– Proc. Natl. Acad. Sci. USA89, 539. ArticlePubMedCASGoogle Scholar
• S hall S. –1995– Biochimie 77, 313. ArticlePubMedCASGoogle Scholar
• S prang S.R., A charya K.R., G oldsmith E.J., S tuart D.I., V arvill K., F etterick R.J., M adsen N.B. & J ohnson L.N. –1988– Nature336, 215. ArticlePubMedCASGoogle Scholar

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Authors and Affiliations

1. Université Paris-Sud XI, UMR CNRS, Inst. Biochimie, Biophysique, Batiment 430, 91405, Orsay, France Dr. Jeannine Yon-Kahn
2. Labo. Biochimie des Signaux, Université Paris VI, CNRS UMR 7631, 96 bd. Raspail, 75006, Paris, France Prof. Guy Hervé

1. Dr. Jeannine Yon-Kahn